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Low Pressure Side of the Pump

Even with good degassing techniques, solvent allowed to stagnate in Teflon® delivery tubing can often reabsorb gas by osmosis through the tubing wall. This often causes bubbles to form in the delivery line between the reservoir and the pump. If allowed to pass into the pump head(s), these bubbles could become lodged in the pump head cavity and cause flow rate fluctuations and disturbances. To counter this, Upchurch Scientific® manufactures two Prime/Purge Valves designed for the low pressure side of the pump — one a universal valve for use with virtually any pumping system and the other specifically made for older-style Waters® pumps.

The universal valve is the V-321, which connects inline along the inlet solvent flow path. You actuate the valve with a simple twist of a luer-lock syringe. The valve and connected syringe let you withdraw solvent at high flow rates, thus removing residual air bubbles from the flow path and preventing them from reaching your pump head. Removing the syringe closes valve's priming port, allowing continuous, gas-free solvent delivery to the pump. If you have a Waters pump, we recommend our V-320 valve, a unit designed to directly replace Waters' old-style priming system with the same easy actuation employed in the V-321.

We often receive questions about using some sort of inline filter along the solvent delivery line. In general, we do not recommend using any inline solvent filter prior to the pump, as cavitation may occur in the pump head. This may cause irregular flow and subsequent poor chromatographic performance. To filter your solvent prior to the pump, we recommend using only our inlet solvent filters. (See Solvent Reservoir tech info page.)



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